侯悦

时间:2020-07-20浏览:11

侯悦,女,博士,现任新万博体育app官网副院长,教授,博士生导师,中国药理学会中药与天然药物药理专业委员会委员。2005年毕业于沈阳药科大学获得药理学博士学位。主要研究方向为神经药理学及中药药理学。作为负责人主持国家自然基金面上项目、国家自然科学基金联合基金项目、国家自然科学基金青年基金项目、中国博士后科学基金、辽宁省高等学校优秀人才支持计划、教育部高等学校博士学科点专项科研基金、辽宁省教育厅科学技术研究项目等多项课题,作为课题副组长参加国家科技重大专项课题3项。曾获辽宁省优秀博士学位论文、辽宁省自然科学学术成果二等奖及三等奖。目前,在国际学术期刊上发表SCI收载文章57篇,其中第一作者或通讯作者37篇。



科研方向

主要研究方向为神经药理学及中药药理学。



基金项目

  1. 国家自然科学基金面上项目:以抑制小胶质细胞活化为靶标探索龙血竭抗阿尔茨海默病的物质基础及作用机制,项目负责人

  2. 国家自然科学基金联合基金项目:阿魏属特征性成分倍半萜香豆素抑制小胶质细胞活化的构效关系及作用机制研究,项目负责人

  3. 国家自然科学基金青年基金:小胶质细胞-MAPK-PIC在精神分裂症中的作用机制研究,项目负责人

  4. 辽宁省高等学校优秀人才支持计划:第一层次人才,项目负责人

  5. 教育部基本科研业务费创新团队建设项目:BAP31在重大疾病中的作用研究,项目负责人

  6. 中国博士后科学基金:天然药物中肿瘤多药耐药逆转剂与抗癌药的复方筛选及作用机制研究,项目负责人

  7. 辽宁省科学技术基金项目:基于高通量筛选的抗老年痴呆活性样品发现及其作用研究,项目负责人

  8. 辽宁省教育厅创新团队项目:抗老年痴呆新药—白藜芦醇衍生物RV的研究与开发,项目负责人

  9. 国家科技重大专项课题:动物实验和药效学评价试验技术子平台,项目副组长

  10. 国家科技重大专项课题:抗老年痴呆一类新药BQGY-8的研究开发,项目副组长

  11. 国家科技重大专项课题:临床前WF-210的研究开发,项目副组长



代表性论文(第一作者或通讯作者论文)

1.Hou Y, Zhang Y, Mi Y, Wang J, Zhang H, Xu J, Yang Y, Liu J, Ding L, Yang J, Chen G, Wu C. A novel quinolyl-substituted analogue of resveratrol inhibits LPS-induced inflammatory responses in microglial cells by blocking the NF-κB/MAPK signaling pathways. Mol Nutr Food Res. 2019 Oct; 63(20): e1801380.

2.Hou Y, Li N, Xie G, Wang J, Yuan Q, Jia C, Liu X, Li G, Tang Y, Wang B. Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-activated microglia via inhibition of MAPK signaling pathways. Journal of Functional Foods. 2015 Dec; 19:676-687.

3.Hou Y, Xie GB, Miao FR, Ding L, Mou Y, Wang L, Su G, Chen G, Yang J, Wu C. Pterostilbene attenuates lipopolysaccharide-induced learning and memory impairment possibly via inhibiting microglia activation and protecting neuronal injury in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Oct 3; 54:92-102.

4.Hou Y, Zhang H, Xie G, Cao X, Zhao Y, Liu Y, Mao Z, Yang J, Wu C. Neuronal injury, but not microglia activation, is associated with ketamine-induced experimental schizophrenic model in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Aug 1; 45:107-16.

5.Liu J, Xu J, Mi Y, Yang Y, Li Q, Zhou D, Wei K, Chen G, Li, Hou Y. Pterostilbene alleviates cerebral ischemia and reperfusion injury in rats by modulating microglial activation. Food Funct. 2020 Jun 24; 11(6):5432-5445.

6.Zhang W, Mi Y, Jiao K, Xu J, Guo T, Zhou D, Zhang X, Ni H, Sun Y, Wei K, Li N, Hou Y, Kellerin alleviates cognitive impairment in mice after ischemic stroke by multiple mechanisms. Phytother Res. 2020 Mar 23. doi: 10.1002/ptr.6676.

7.Zhou D, Chang W, Liu B, Chen G, Yang Y, Hao Y, Hou Y, Li N. Stilbenes from the tubers of Bletilla striata with potential anti-neuroinflammatory activity. Bioorg Chem. 2020 Apr; 97:103715.

8.Zhou D, Li Y, Chen G, Yang Y, Mi Y, Lin B, Li W, Hou Y, Li N. Structural elucidation and anti-neuroinflammatory activities of lignans from the testas of Vernicia montana. Bioorg Chem. 2020 Apr; 97:103690.

9.Chen G, Zhao W, Li Y, Zhou D, Ding J, Lin B, Li W, Yang Y, Liu J, Hou Y, Li N. Bioactive chemical constituents from the seed testa of Vernicia fordii as potential neuroinflammatory inhibitors. Phytochemistry. 2020 Mar; 171:112233.

10.Liu X, Jiao K, Jia CC, Li GX, Yuan Q, Xu JK, Hou Y, Wang B. BAP31 regulates IRAK1-dependent neuroinflammation in microglia. J Neuroinflammation. 2019 Dec 28; 16(1):281.

11.Zhou D, Chen G, Ma YP, Wang CG, Lin B, Yang YQ, Li W, Koike K, Hou Y, Li N. Isolation, Structural Elucidation, Optical Resolution, and Antineuroinflammatory Activity of Phenanthrene and 9,10-Dihydrophenanthrene Derivatives from Bletilla striata. J Nat Prod. 2019 Aug 23; 82(8):2238-2245.

12.Xiao J, Hao T, Chen G, Song J, Lin B, Li W, Xu J, Liu J, Hou Y, Li N. Natural neuroprotective alkaloids from Stephania japonica (Thunb.) Miers. Bioorg Chem. 2019 Oct; 91:103175.

13.Zhang GJ, Pan QM, Zhang YL, Liao HB, Yang YQ, Hou Y, Liang D. Coumarinolignoids and Taraxerane Triterpenoids from Sapium discolor and Their Inhibitory Potential on Microglial Nitric Oxide Production. J Nat Prod. 2018 Oct 26; 81(10):2251-2258.

14.Chen R, Yang YQ, Xu J, Pan Y, Zhang W, Xing Y, Ni H, Sun Y, Hou Y, Li N. Tamarix hohenackeri Bunge exerts anti-neuroinflammatory effects on lipopolysaccharide-activated microglia in vitro. Phytomedicine. 2018 Feb 1; 40:10-19.

15.Li J, Li N, Li X, Chen G, Wang C, Lin B, Hou Y. Characteristic α-Acid Derivatives from Humulus lupulus with Antineuroinflammatory Activities. J Nat Prod. 2017 Dec 22; 80(12):3081-3092.

16.Zhao WH, Li N, Chu Y, Sun T, Wang J, Wang WL, Li JY, Lin B, Chen R, Hou Y. Novel cycloneolignans from Vernicia fordii with inhibitory effects on over-activation of BV2 cells in vitro. Sci Rep. 2017 Oct 19; 7(1):13608.

17.Li N, Meng D, Pan Y, Cui Q, Li G, Ni H, Sun Y, Qing D, Jia X, Pan Y, Hou Y. Anti-neuroinflammatory and NQO1 inducing activity of natural phytochemicals from Coreopsis tinctoria. Journal of Functional Foods. 2015; 17: 837-846.

18.Li N, Ma Z, Li M, Xing Y, Hou Y. Natural potential therapeutic agents of neurodegenerative diseases from the traditional herbal medicine Chinese dragon's blood. J Ethnopharmacol. 2014 Mar 28; 152(3):508-521.



联系方式

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