盛韧

时间:2020-04-14浏览:44

个人信息

Name: Ren Sheng/盛韧

Title: Ph.D.

Major: Biochemistry/Cell biology

Email: shengren@mail.neu.edu.cn

            shengren1211@126.com



教育及研究经历


B.S. in Chemistry at Jilin University, Dept. of Chemistry, China

From 09/2004 to 06/2008


Ph.D. in Chemistry/Biochemistry at University of Illinois at Chicago (UIC), Department of Chemistry, USA

From 08/2008 to 12/2013,

With Dr.Wonhwa Cho


Postdoc fellow at UIC, Department of Chemistry, USA

From 01/2014 to 04/2015,

With Dr. Wonhwa Cho


Postdoc fellow at Boston Children’s Hospital/Harvard Medical School, USA

From 05/2015 to 07/2018,

With Dr. Xi He


Professor at Northeastern University, Colloge of Life and Health Science, China

Since 08/2018


Member of Key Laboratory of Data Analytics and Optimization for Smart Industry (Northeastern University), Ministry of Education, China,

Since 03/2019




Title & Awards


中国健康管理协会标准化与评价分会委员,2018

辽宁省组织部“兴辽英才计划”“青年拔尖”人才,2018

东北大学“海外百人计划”特聘教授,2018


研究方向


Cellular signaling;

lipid metabolism;

cancer biology;

organoid research.


基金项目


1. 东北大学“海外百人计划”资助,200万,2018.7-2022.12

2. 中央高校基本科研业务费,N16100300120万,2018.7-2018.12

3. 兴辽英才计划“青年拔尖人才”,XLYC180723950万,2019.1-2021.12

4. 中央高校基本科研专项资金资助“优青培育”计划,N18200500625万,2019.1-2021.12

5. 国家自然科学基金面上项目,3197072158万,2020.1-2023.12

6. 国家自然科学基金青年基金项目,8190283020.5万,2020.1-2022.12



Peer-reviewed Publications


1. Genome-wide identification and functional annotation of dual specificity protein- and lipid-binding modules that modulate protein interactions at the membrane.

Chen Y*, Sheng R*, Kallberg M, R. Silkov A, Tun MP, Bhardwaj N, Kurilova S, Hall RA, Honig B, Lu H, and Cho W. (*co-first authors with equal contribution)

Mol Cell ,2012 Apr 27;46(2):226-37.

  

2. Cholesterol modulates cell signaling and protein networking by specifically interacting with scaffold proteins.

Sheng R, Chen Y, Yung Gee H, Stec E, Melowic HR, Blatner NR, Tun MP, Kim Y, Källberg M, Fujiwara TK, Hye Hong J, Pyo Kim K, Lu H, Kusumi A, Goo Lee M, Cho W.

Nat Commun, 2012;3:1249.

  

3. Non-canonical role of the PDZ4 domain of the adaptor protein PDZK1 in the regulation of the hepatic high density lipoprotein receptor scavenger receptor class B, type I (SR-BI).

Tsukamoto K, Wales TE, Daniels K, Pal R, Sheng R, Cho W, Stafford W, Engen JR, Krieger M, Kocher O.

J Biol Chem, 2013, Jul 5;288(27):19845-60.

  

4. Cholesterol selectively activates canonical Wnt signalling over non-canonical Wnt signalling.

Sheng R, Kim H, Lee H, Xin Y, Chen Y, Tian W, Cui Y, Choi JC, Doh J, Han JK, Cho W.

Nat Commun, 2014; 5:4393.

  

5. Simultaneous in situ quantification of two cellular lipid pools using orthogonal fluorescent sensors.

Liu SL, Sheng R, O’Connor MJ, Cui Y, Yoon Y, Kurilova S, Lee D, Cho W.

Angew Chem Int Ed Engl, 2014, Dec 22;53(52):14387-91.

  

6. SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins.

Park MJ*, Sheng R*, Silkov A*, Jung DJ*, Wang ZG, Xin Y, Kim H, Thiagarajan-Rosenkranz P, Song S, Yoon Y, Nam W, Kim I, Kim E, Lee DG, Chen Y, Singaram I, Wang L, Jang MH, Hwang CS, Honig B, Ryu S, Lorieau J, Kim YM, Cho W. (*co-first authors with equal contributionHighlighted by Cell (04/2016), Nature Review in Molecular Cell (05/2016), Cancer Discovery (04/2016) and F1000Prime (04/2016)

Mol Cell , 2016 Apr 7; 62(1): 7-20.

  

7. Raft-based interactions of gangliosides with a GPI-anchored receptor.

Komura N, Suzuki KG, Ando H, Konishi M, Koikeda M, Imamura A, Chadda R, Fujiwara TK, Tsuboi H, Sheng R, Cho W, Furukawa K, Furukawa K, Yamauchi Y, Ishida H, Kusumi A, Kiso M.

Nat Chem Biol, 2016 Jun;12(6):402-10.

  

8. Lipids regulate Lck activity through their interactions with the Lck SH2 domain.

Sheng R, Jung DJ, Silkov A, Kim H, Wang ZG, Xin Y, Kim E, Park MJ, Thiagarajan-Rosenkranz P, Honig B, Beak K, Ryu S, Lorieau J, Kim YM, Cho W.

J Biol Chem,2016 Aug 19;291(34):17639:50.

  

9. Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol.

Liu SL*, Sheng R*, Jung JH, Wang L, Stec E, O’Connor MJ, Song S, Bikkavilli RK, Winn R, Lee D, Baek K, Ueda K, Levitan I, Kim KP, Cho W. (*co-first authors with equal contribution)

Nat Chem Biol 2017 Mar;13(3):268-274.

  

10. Fluorescence-based in situ quantitative imaging for cellular lipids.

Cho W, Yoon Y, Liu SL, Baek K, Sheng R.

Methods Enzymol2017;583:19-33.

  

11. CDKL3 promotes osteosarcoma progression by activating Akt/PKB

He A, Ma L, Huang Y, Zhang H, Duan W, Li Z, Fei T, Huang W, Wu H, Liu L, Yuan J, Bai Y, Dai W, Wang Y, Li H, Sun Y, Wang Y, Wang C, Yuan T, Yang Q, Tian S, Dong M, Sheng R*, Xiang D*(*co-corresponding).

Life Sci Alliance 2020 Mar 31;3(5).