费腾

时间:2019-07-15浏览:1950

 

费腾

博士,教授,博士生导师

海外高层次人才引进计划入选者,辽宁省百千万人才工程千人层次(2017),东北大学海外百人青年特聘教授。

 

教育和工作经历

2001-2005  东北大学生物工程专业,学士

2005-2010  清华大学生命科学学院,博士

2011-2016  哈佛大学医学院/Dana-Farber癌症研究所,博士后

2016- 新万博体育app官网,教授,博导

 

主要科研方向

本课题组主要运用多种高通量的功能基因组学结合精细的分子细胞学研究手段,探讨肿瘤、代谢性疾病以及干细胞领域相关的重大问题。鉴定参与上述过程的重要功能基因、基因元件以及非编码RNA等,深入探讨其分子机制,为疾病精准诊疗及再生医学提供理论和实践支持。

 

本课题组正积极招收相关领域博士后,欢迎加盟!

课题组网站:http://faculty.neu.edu.cn/feiteng/index.html

代表性论文

 (*co-first author; #corresponding author)

[1] Jeselsohn R, Bergholz JS, Pun M, Cornwell M, Liu W, Nardone A, Xiao T, Li W, Qiu X, Buchwalter G, Feiglin A, Abell-Hart K, Fei T, Rao P, Long H, Kwiatkowski N, Zhang T, Gray N, Melchers D, Houtman R, Liu XS, Cohen O, Wagle N, Winer EP, Zhao J, Brown M. Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations. Cancer Cell. 2018 Feb 12;33(2):173-186.e5.

[2] Willis S, Sun Y, Abramovitz M, Fei T, Young B, Lin X, Ni M, Achua J, Regan MM, Gray KP, Gray R, Wang V, Long B, Kammler R, Sparano JA, Williams C, Goldstein LJ, Salgado R, Loi S, Pruneri G, Viale G, Brown M, Leyland-Jones B. High Expression of FGD3, a Putative Regulator of Cell Morphology and Motility, Is Prognostic of Favorable Outcome in Multiple Cancers. JCO Precision Oncology. 2017 :1, 1-13. DOI: https://doi.org/10.1200/PO.17.00009

[3] Fei T#. Targeting RNA binding protein in prostate cancer. Mol Cell Oncol. 2017 Jul 17;4(5):e1353855. doi: 10.1080/23723556.2017.1353855. eCollection 2017. PMID: 29057311

[4] Fei T*#, Chen Y*, Xiao T, Li W, Cato L, Zhang P, Cotter MB, Bowden M, Lis RT, Zhang SG, Wu Q, Feng FY, Loda M, He HH, Liu XS#, Brown M#. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5207-E5215. doi: 10.1073/pnas.1617467114. Epub 2017 Jun 13. PMID: 28611215

[5] Guo H, Ahmed M, Zhang F, Yao CQ, Li S, Liang Y, Hua J, Soares F, Sun Y, Langstein J, Li Y, Poon C, Bailey SD, Desai K, Fei T, Li Q, Sendorek DH, Fraser M, Prensner JR, Pugh TJ, Pomerantz M, Bristow RG, Lupien M, Feng FY, Boutros PC, Freedman ML, Walsh MJ, He HH. Modulation of long noncoding RNAs by risk SNPs underlying genetic predispositions to prostate cancer. Nat Genet. 2016 Oct;48(10):1142-50. doi: 10.1038/ng.3637. PMID: 27526323

[6] Du Z, Sun T, Hacisuleyman E, Fei T, Wang X, Brown M, Rinn JL, Lee MG, Chen Y, Kantoff PW, Liu XS. Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer. Nat Commun. 2016 Mar 15;7:10982. doi: 10.1038/ncomms10982. PMID: 26975529

[7] Liu Y, Fei T, Zheng X, Brown M, Zhang P, Liu XS, Wang H. An Integrative Pharmacogenomic Approach Identifies Two-drug Combination Therapies for Personalized Cancer Medicine. Sci Rep. 2016 Feb 26; 6:22120. doi: 10.1038/ srep22120. PMID: 26916442

[8] Zhu G, Fei T, Li Z, Yan X, Chen YG. Activin Regulates Self-renewal and Differentiation of Trophoblast Stem Cells by Down-regulating the X Chromosome Gene Bcor. J Biol Chem. 2015 Sep 4;290(36):22019-29. PMID: 26221038

[9] Wang H, Zheng X, Fei T, Wang J, Li X, Liu Y, Zhang F. Towards pathway-centric cancer therapies via pharmacogenomic profiling analysis of ERK signaling pathway. Clin Transl Med. 2015 Dec;4(1):66. PMID: 26220863

[10] Hsieh CL, Fei T, Chen Y, Li T, Gao Y, Wang X, Sun T, Sweeney CJ, Lee GS, Chen S, Balk SP, Liu XS, Brown M, Kantoff PW. Enhancer RNAs participate in androgen receptor-driven looping that selectively enhances gene activation. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7319-24. PMID: 24778216

[11] He HH, Meyer CA, Hu SS, Chen MW, Zang C, Liu Y, Rao PK, Fei T, Xu H, Long H, Liu XS, Brown M. Refined DNase seq protocol and data analysis reveals intrinsic bias in transcription factor footprint identification. Nat Methods. 2014 Jan;11(1):73-8. PMID: 24317252

[12] Wang H, Meyer CA, Fei T, Wang G, Zhang F, Liu XS. A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer. BMC Genomics. 2013 Oct 4;14(1):680. PMID: 24093963

[13] Du Z*, Fei T*, Verhaak RG, Su Z, Zhang Y, Brown M, Chen Y*, Liu XS. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Nat Struct Mol Biol. 2013 Jul;20(7):908-13. PMID: 23728290 (* as co-first author)

[14] Ni M, Chen Y, Fei T, Li D, Lim E, Liu XS, Brown M. Amplitude modulation of androgen signaling by c-MYC. Genes Dev. 2013 Apr 1;27(7):734-48. PMID: 23530127

[15] Zhang J*, Fei T*, Li Z*, Zhu G, Wang L, Chen YG. BMP induces cochlin expression to facilitate self-renewal and suppress neural differentiation of mouse embryonic stem cells. J Biol Chem. 2013 Mar 22;288(12):8053-60. PMID: 23344953 (* as co-first author)

[16] Li Z*, Fei T*, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG. BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell. 2012 Feb 3;10(2):171-82. PMID: 22305567 (* as co-first author)

[17] Sun Y*, Fei T*, Yang T*, Zhang F, Chen YG, Li H, Xu Z. The suppression of CRMP2 expression by BMP-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem. 2010 Dec 10; 285(50):39039-50. PMID: 20926379 (* as co-first author)

[18] Fei T, Zhu S, Xia K, Zhang J, Li Z, Han JD, Chen YG. Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells. Cell Res. 2010 Dec; 20(12):1306-18. PMID: 21079647

[19] Fei T, Chen YG. Regulation of embryonic sem cell self-renewal and differentiation by TGF-β family signaling. Sci China Life Sci. 2010 Apr; 53(4):497-503. PMID: 20596917

[20]Fei T*, Xia K*, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Xiao H, Han J, Chen YG. Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination. Genome Res. 2010 Jan; 20(1):36 44. PMID: 19926752

[21] Zhang S, Fei T, Zhang L, Zhang R, Chen F, Ning Y, Han Y, Feng XH, Meng A, Chen YG. Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation. Mol Cell Biol. 2007 Jun; 27(12):4488-99. PMID: 17438144

[22] Huang W, Chang HY, Fei T, Wu H, Chen YG. GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2007 Apr 12; 26(17):2471-82. PMID: 17043650

[23] Ma J, Wang Q, Fei T, Han JD, Chen YG. MCP-1 mediates TGF-beta-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood. 2007 Feb 1; 109(3):987-94. PMID: 17032917

 

 

 

联系方式

地址:沈阳市浑南区创新路195号,新万博体育app官网生物技术研究所

邮编:110169

办公电话:024-83656103

Email: feiteng@mail.neu.edu.cn

Website: http://faculty.neu.edu.cn/feiteng